Lutein Inhibits the Migration of Retinal Pigment Epithelial Cells via Cytosolic and Mitochondrial Akt Pathways (Lutein Inhibits RPE Cells Migration)
Identifieur interne : 000139 ( Main/Exploration ); précédent : 000138; suivant : 000140Lutein Inhibits the Migration of Retinal Pigment Epithelial Cells via Cytosolic and Mitochondrial Akt Pathways (Lutein Inhibits RPE Cells Migration)
Auteurs : Ching-Chieh Su [Taïwan] ; Chi-Ming Chan [Taïwan] ; Han-Min Chen ; Chia-Chun Wu ; Chien-Yu Hsiao [Taïwan] ; Pei-Lan Lee ; Victor Chia-Hsiang Lin ; Chi-Feng HungSource :
- International Journal of Molecular Sciences ; 2014.
English descriptors
- KwdEn :
- Cell Line, Cell Movement (drug effects), Cytosol (metabolism), Humans, Lutein (pharmacology), Mitochondria (drug effects), Mitochondria (metabolism), Proto-Oncogene Proteins c-akt (genetics), Proto-Oncogene Proteins c-akt (metabolism), Proto-Oncogene Proteins c-sis (pharmacology), Retinal Pigment Epithelium (cytology), Retinal Pigment Epithelium (drug effects), Retinal Pigment Epithelium (metabolism), Signal Transduction (drug effects).
- MESH :
- chemical , genetics : Proto-Oncogene Proteins c-akt.
- chemical , metabolism : Proto-Oncogene Proteins c-akt.
- chemical , pharmacology : Lutein, Proto-Oncogene Proteins c-sis.
- cytology : Retinal Pigment Epithelium.
- drug effects : Cell Movement, Mitochondria, Retinal Pigment Epithelium, Signal Transduction.
- metabolism : Cytosol, Mitochondria, Retinal Pigment Epithelium.
- Cell Line, Humans.
Abstract
During the course of proliferative vitreoretinopathy (PVR), the retinal pigment epithelium (RPE) cells will de-differentiate, proliferate, and migrate onto the surfaces of the sensory retina. Several studies have shown that platelet-derived growth factor (PDGF) can induce migration of RPE cells via an Akt-related pathway. In this study, the effect of lutein on PDGF-BB-induced RPE cells migration was examined using transwell migration assays and Western blot analyses. We found that both phosphorylation of Akt and mitochondrial translocation of Akt in RPE cells induced by PDGF-BB stimulation were suppressed by lutein. Furthermore, the increased migration observed in RPE cells with overexpressed mitochondrial Akt could also be suppressed by lutein. Our results demonstrate that lutein can inhibit PDGF-BB induced RPE cells migration through the inhibition of both cytoplasmic and mitochondrial Akt activation.
Url:
DOI: 10.3390/ijms150813755
PubMed: 25110866
PubMed Central: 4159823
Affiliations:
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E-Mail:<email>suk.ccsu@gmail.com</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijms-15-13755">Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City 23148, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City 23148</wicri:regionArea><wicri:noRegion>New Taipei City 23148</wicri:noRegion></affiliation><affiliation><nlm:aff id="af3-ijms-15-13755">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>m212092001@tmu.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Chan, Chi Ming" sort="Chan, Chi Ming" uniqKey="Chan C" first="Chi-Ming" last="Chan">Chi-Ming Chan</name><affiliation><nlm:aff id="af3-ijms-15-13755">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>m212092001@tmu.edu.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-15-13755">Department of Ophthalmology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Ophthalmology, Cardinal Tien Hospital, New Taipei City 23148</wicri:regionArea><wicri:noRegion>New Taipei City 23148</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Han Min" sort="Chen, Han Min" uniqKey="Chen H" first="Han-Min" last="Chen">Han-Min Chen</name><affiliation><nlm:aff id="af5-ijms-15-13755">Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>056489@mail.fju.edu.tw</email></nlm:aff></affiliation></author><author><name sortKey="Wu, Chia Chun" sort="Wu, Chia Chun" uniqKey="Wu C" first="Chia-Chun" last="Wu">Chia-Chun Wu</name><affiliation><nlm:aff id="af6-ijms-15-13755">Department of Life Sciences, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>bobwu80113@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Hsiao, Chien Yu" sort="Hsiao, Chien Yu" uniqKey="Hsiao C" first="Chien-Yu" last="Hsiao">Chien-Yu Hsiao</name><affiliation><nlm:aff id="af7-ijms-15-13755">Department of Nutrition and Health Science, Chang Guang University of Science and Technology, Taoyuan 33303, Taiwan; E-Mail:<email>mozart@gw.cgust.edu.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af8-ijms-15-13755">Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303</wicri:regionArea><wicri:noRegion>Taoyuan 33303</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Pei Lan" sort="Lee, Pei Lan" uniqKey="Lee P" first="Pei-Lan" last="Lee">Pei-Lan Lee</name><affiliation><nlm:aff id="af9-ijms-15-13755">Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America, Boston, MA 02215, USA; E-Mail:<email>peilan@bu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Lin, Victor Chia Hsiang" sort="Lin, Victor Chia Hsiang" uniqKey="Lin V" first="Victor Chia-Hsiang" last="Lin">Victor Chia-Hsiang Lin</name><affiliation><nlm:aff id="af10-ijms-15-13755">Department of Urology, E-Da Hospital, Taiwan and School of Medicine for International Students, I-Shou University, Kaohsiung 84001, Taiwan; E-Mail:<email>ed102161@edah.org.tw</email></nlm:aff></affiliation></author><author><name sortKey="Hung, Chi Feng" sort="Hung, Chi Feng" uniqKey="Hung C" first="Chi-Feng" last="Hung">Chi-Feng Hung</name><affiliation><nlm:aff id="af3-ijms-15-13755">School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan; E-Mail:<email>m212092001@tmu.edu.tw</email></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="e-ISSN">1422-0067</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line</term><term>Cell Movement (drug effects)</term><term>Cytosol (metabolism)</term><term>Humans</term><term>Lutein (pharmacology)</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Proto-Oncogene Proteins c-akt (genetics)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Proto-Oncogene Proteins c-sis (pharmacology)</term><term>Retinal Pigment Epithelium (cytology)</term><term>Retinal Pigment Epithelium (drug effects)</term><term>Retinal Pigment Epithelium (metabolism)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lutein</term><term>Proto-Oncogene Proteins c-sis</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Movement</term><term>Mitochondria</term><term>Retinal Pigment Epithelium</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cytosol</term><term>Mitochondria</term><term>Retinal Pigment Epithelium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During the course of proliferative vitreoretinopathy (PVR), the retinal pigment epithelium (RPE) cells will de-differentiate, proliferate, and migrate onto the surfaces of the sensory retina. Several studies have shown that platelet-derived growth factor (PDGF) can induce migration of RPE cells via an Akt-related pathway. In this study, the effect of lutein on PDGF-BB-induced RPE cells migration was examined using transwell migration assays and Western blot analyses. We found that both phosphorylation of Akt and mitochondrial translocation of Akt in RPE cells induced by PDGF-BB stimulation were suppressed by lutein. Furthermore, the increased migration observed in RPE cells with overexpressed mitochondrial Akt could also be suppressed by lutein. Our results demonstrate that lutein can inhibit PDGF-BB induced RPE cells migration through the inhibition of both cytoplasmic and mitochondrial Akt activation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ryan, S J" uniqKey="Ryan S">S.J. Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simo, R" uniqKey="Simo R">R. 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Johnson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chen, Han Min" sort="Chen, Han Min" uniqKey="Chen H" first="Han-Min" last="Chen">Han-Min Chen</name><name sortKey="Hung, Chi Feng" sort="Hung, Chi Feng" uniqKey="Hung C" first="Chi-Feng" last="Hung">Chi-Feng Hung</name><name sortKey="Lee, Pei Lan" sort="Lee, Pei Lan" uniqKey="Lee P" first="Pei-Lan" last="Lee">Pei-Lan Lee</name><name sortKey="Lin, Victor Chia Hsiang" sort="Lin, Victor Chia Hsiang" uniqKey="Lin V" first="Victor Chia-Hsiang" last="Lin">Victor Chia-Hsiang Lin</name><name sortKey="Wu, Chia Chun" sort="Wu, Chia Chun" uniqKey="Wu C" first="Chia-Chun" last="Wu">Chia-Chun Wu</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Su, Ching Chieh" sort="Su, Ching Chieh" uniqKey="Su C" first="Ching-Chieh" last="Su">Ching-Chieh Su</name></noRegion><name sortKey="Chan, Chi Ming" sort="Chan, Chi Ming" uniqKey="Chan C" first="Chi-Ming" last="Chan">Chi-Ming Chan</name><name sortKey="Hsiao, Chien Yu" sort="Hsiao, Chien Yu" uniqKey="Hsiao C" first="Chien-Yu" last="Hsiao">Chien-Yu Hsiao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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